How Thyroid Hormone Plays Crucial Role In Musculoskeletal System

Nestled within our bodies, the thyroid gland stands as a silent architect, orchestrating the symphony of various physiological processes. While its role in regulating metabolism and energy levels is widely acknowledged, a lesser-known yet crucial aspect of its influence extends to the intricate realm of our muscles, particularly the skeletal muscles.

Thyroid hormone (TH) is not just a metabolic maestro; it also plays a crucial role in normal endochondral ossification, contributing to skeletal development, linear growth, maintenance of bone mass, and even efficient fracture healing.

Crucial for overall bodily functions, thyroid hormones extend their influence on our muscles, especially the skeletal ones. Deep within our muscles, there exist essential elements known as DIO2 and DIO3. DIO2 plays a key role by transforming a hormone called T4 into an active form named T3. This T3 can either remain within the muscle cells or venture outside, affecting neighbouring cells. On the flip side, DIO3 deactivates T3.

This intricate system operates like a smart regulator, finely adjusting the levels of T3 within our muscle cells. This process is particularly significant during various stages of muscle development, offering insights into the delicate dance of growth and repair within our bodies.

In simpler terms, thyroid hormones are pivotal for maintaining the well-being of our muscles and assisting in their growth. The local regulation of T3 activity by our body introduces a new avenue of understanding that could potentially lead to innovative approaches in aiding individuals dealing with muscle-related issues or injuries. As we unravel the secrets of the thyroid-muscle connection, we pave the way for a deeper comprehension of the body's intricate mechanisms and potential avenues for targeted interventions in muscle health.

Authored by Dr Sarita Karsh (PT), Senior Physiotherapist and Quality Manager at Healyos, a physiotherapist with over 10 years of treating patients, certified manual therapist and an expert in geriatric care.